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How can I simulate a 1-compartment PK and Indirect Turnover PD Model within the Simbiology Graphical Interface?

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Andy
Andy 2017-2-3
编辑： Andy 2017-2-7
Hi, Do you have an graphical Simbiology example that would allow me to simulate a PK/PD Model in Simbiology model for a 1-compartment PK Model with a Indirect PD Turnover with the following equation: dR(t)/dt = kin*(Baseline-(Emax*C(t)^gamma)/(EC50^n+C(t)^gamma)) - kout*R(t) where kin=kout*R0, based on steady-state solution R'(t)=0=kin-kout*R(0) for C(0)=0.
This PD model is a slight modification from the current Matlab code: https://www.mathworks.com/matlabcentral/fileexchange/43521-preclinical-pkpd-modeling/content/MatlabShared_20140915/PD_turnover_stimOfProd_ode.m
I want to just do this using a graphical interface in Simbiology.
Thank you for your help.

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回答（2 个）

Arthur Goldsipe
Arthur Goldsipe 2017-2-6
编辑：Arthur Goldsipe 2017-2-7
Here are course materials that include a warfarin model.
Here are two other example PKPD models:
You might also find the following links helpful:
Andy
Andy 2017-2-7
编辑：Andy 2017-2-7
Thanks Arthur for the reply and the website links.
This was very helpful.

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