Corrected p-value during correlation analysis

Question

Sahil Bajaj 2017-2-20

0
链接

此问题的直接链接

https://ww2.mathworks.cn/matlabcentral/answers/325875-corrected-p-value-during-correlation-analysis

评论： Star Strider 2017-2-20

Hi everyone,

I am interested in doing multiple corrections while doing some correlation analysis.

I have brain thickness data of 50 subject's 14 brain networks: 7 networks on left hemisphere and 7 networks on right hemisphere i.e. X = 50x7x2. I would like to see whether thickness of each network of these 50 subjects is correlated with age i.e. my age variable is a vector of size 50 values i.e. Y = 50x1.

Could you please tell me how and which MATLAB program can I use to estimate 14 correlation coefficient values and corrected p-value of each of these correlations?

Thanks a lot.

0 个评论
显示 -2更早的评论隐藏 -2更早的评论

请先登录，再进行评论。

请先登录，再回答此问题。

Answer 1

Walter Roberson 2017-2-20

0
链接

此回答的直接链接

https://ww2.mathworks.cn/matlabcentral/answers/325875-corrected-p-value-during-correlation-analysis#answer_255472

在 MATLAB Online 中打开

T1 = reshape(thicknesses, [], 14);
T2  = reshape(ages, [], 1);
T3 = [T1, T2];
c = cov(T3);
correlations_you_care_about = reshape( c(end,1:end-1), 7, 2);

1 个评论
显示 -1更早的评论隐藏 -1更早的评论

Sahil Bajaj 2017-2-20

编辑：Sahil Bajaj 2017-2-20

Hi Walter, Thanks for your reply. In the last line, correlations_you_care_about = reshape( c(end,1:end-1), 7, 2); I am not sure how reshape( c(end,1:end-1), 7, 2); will calculate correlations and p-values. Are there typos in this line?

请先登录，再进行评论。

Answer 2

Star Strider 2017-2-20

0
链接

此回答的直接链接

https://ww2.mathworks.cn/matlabcentral/answers/325875-corrected-p-value-during-correlation-analysis#answer_255474

I would do a regression. See the ‘Statistical Analysis’ section in ‘Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults.’ Aging Cell. 2014 Dec;13(6):1068-74.

If you have the Statistics and Machine Learning Toolbox, you can do the sort of categorical regression they discuss, with multiple comparisons. The most obvious reason to adapt their statistical analysis procedure is that these authors have published in a refereed journal, and you would be using an accepted technique.

There may be other papers with statistical analysis techniques better suited to your experimental design. Search PubMed with the search string brain & volume & age for all 12276 similar articles.

I wish you success in your research.