Exclude calculation in a part of array

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I have created 300 by 300 array and I am interested to perform calculation for the space as shown in attached image. How can I exclude some part of array from main calculation?
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Adam
Adam 2017-6-22
Assuming you have the area define by a logical mask then just apply the mask to your data. It will collapse it to 1d, but that is fine if it is a per-point calculation. You can then put the results back into the original shape after.

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