How to change PDE coefficients in specific nodes?

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MG
MG 2017-6-30
Hi users,
I am solving a water diffusion problem in a 2D planar domain. I am using a Matlab code, not the PDETool GUI. I have all the PDE coefficients expressed as a function of the time and the script works so well at the moment.
In the next step, I need to add a perturbation in the problem altering one of the PDE coefficients (the 'c' coefficient) in specific nodes of the mesh.
Does MATLAB allow this?
Thanks in advance
MG

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