I am not sure of what do you mean by simulating a matrix in Simulink. If you just want to multiply the matrix with a vector having variables, it can be done in the MATLAB command window by entering the following commands-
>> syms q0 q1c q1s vc0 vc1 vc2
>> [ 1 - q0 -0.5*q1c -0.5*q1s; -q1c 1 - q0 0;q1s 0 1 - q0]*[vc0;vc1;vc2]
ans =
- (q1c*vc1)/2 - (q1s*vc2)/2 - vc0*(q0 - 1)
- q1c*vc0 - vc1*(q0 - 1)
q1s*vc0 - vc2*(q0 - 1)
The resulting answer is a 3x1 vector as expected. Please note the 'syms' command is a function of Symbolic Math Toolbox, details provided in the link below -