time dependent sensitivity analysis

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Deepa Maheshvare 2017-11-3

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评论： Deepa Maheshvare 2017-11-6

I would like to get some advice on how to perform a time dependent sensitivity analysis in SimBiology.For,instance in COPASI tool there is an option to do sensitivity analysis for a system which has achieved a steady state.I wish to perform the same kind of analysis for non-steady state systems.i.e perturb the kinetics of an enzyme and see how the metabolite rate changes.

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Answer 1

Arthur Goldsipe 2017-11-3

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SimBiology has functionality for performing sensitivity analysis. Here’s an example that uses the command-line interface: G-Protein Example. You can also perform sensitivity analysis from the SimBiology Desktop (graphical interface).

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Deepa Maheshvare 2017-11-6

Many thanks for the advice. I tried importing SBML file of a model.An error is displayed"Simbiology version 55. does not support SBML functions.Backup the original SBML file to avoid losing any function definitions.'

I continued by adding a task and trying to simulate the model.But the simulation failed. Could you please help me with this?

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