Correlation coefficient between interspike intervals

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Alba Del Rio Serrato
编辑： the cyclist 2018-1-11
Hi,
I´m struggeling a bit calculating the correlation coefficients between the ISIs of my vector, I always get 1 with a p=1 and my basic knowledge tell me that it cannot be correct. So I had voltage values from which I extracted my ISI values in ms, now I need to calculate the correlation coefficient of the intervals.
Any help/explanation? I´m new with this so I ask for patient and understanding!
  2 个评论
Star Strider
Star Strider 2018-1-11
‘... my basic knowledge tell me that it cannot be correct.’
It would seem that the interspike intervals would be correlated. I would plot them as functions of the initial spike time, and see if they form a specific pattern.
It would help if you post at least a representative sample of your spike times and interspike intervals data, as well as your code, and a description of the hypothesis you are testing. We might be able to suggest a better approach than a linear correlation.
Alba Del Rio Serrato
Alba Del Rio Serrato 2018-1-11
编辑：the cyclist 2018-1-11
Voltage = -51.9375000000000 -51.9375000000000 -51.9062000000000 -51.8125000000000 -51.7500000000000 -51.7812000000000 -51.7188000000000 -51.6250000000000 -51.6250000000000 -51.5938000000000 -51.5938000000000 -51.5000000000000 -51.5938000000000 -51.5000000000000 -51.4688000000000 -51.4375000000000 -51.5000000000000 -51.5312000000000 -51.3750000000000 -51.2500000000000 -51.3750000000000 -51.3125000000000 -51.3438000000000 -51.1875000000000 -51.3125000000000 -51.1250000000000 -51.2188000000000 -51.1250000000000 -51.1875000000000 -51.0625000000000 -51.0312000000000 -50.9375000000000 -51 -50.9375000000000 -50.9062000000000 -50.6562000000000 -50.5938000000000 -50.5312000000000 -50.5000000000000 -50.5000000000000 -50.5000000000000 -50.4375000000000 -50.5312000000000 -50.5000000000000 -50.4062000000000 -50.3750000000000 -50.4062000000000 -50.2812000000000 -50.3438000000000 -50.2188000000000
(**Firing rate =0.05 ms) So what I have done to extract the ISIs is:
dt=0.05;
a=length(voltage)*dt;
t=[0:dt:(a-dt)];
v_thres=-20; %set threshold
i=0;
j=0;
NumSpikes=0; %hold number of spikes that have occurred
ISI =[];
for i=2:length(voltage);
if (voltage(i) > v_thres) && (voltage(i-1) < v_thres)
if j==0;
j=i;
else NumSpikes = NumSpikes + 1;
ISI=[ISI (i-j)*dt];
if ((i-j)*dt) < 1;
disp('There is at least one value below the limit.');
end
j=i;
end
end
end
Now I want to calculate the correlation coefficient of intervals, I know based in what they told me about the data, that after a longer intervals seems to come a shorter one.

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