Method to determine the difference between 2 images

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untitled.jpg
I need suggestion on how to differenstiate the diffetence between this 2 images. The help will be much more appreciate =)
Better is with coding explanation.

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Image Analyst
Image Analyst 2019-2-10
There are lots of things that are different between those images, like size, area, count, and shape of dark blobs. See my Image Segmentation Tutorial in my File Exchange

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R2018b

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