How to find a slope of signal if we do not know the value of x1, x2, y1, y2

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How can we find the slope of a signal if we do not know the value of x1, x2, y1, y2
which we cannot use
Slope = (y2 - y1) / (x2 - x1);
Example:
load sunspot.dat
year = sunspot(:,1);
avSpots = sunspot(:,2);
[pks,loc]=findpeaks(avSpots,year, 'Annotate','extents','WidthReference','halfheight')
axis([1700 1711 0 100])
give a graph of
Thank you

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Star Strider
Star Strider 2019-2-13
I am not certain what you intend by ‘slope of a signal’. You can easily determine the derivatives of the signal with the gradient (link) function.
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