How to reduce the effect of one of the manipulated variables in an MPC controller with a MISO model as the internal model?

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Dawn Ivan 2019-4-4

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https://ww2.mathworks.cn/matlabcentral/answers/454325-how-to-reduce-the-effect-of-one-of-the-manipulated-variables-in-an-mpc-controller-with-a-miso-model

I am using a MISO (2 inputs) model as the inernal plant model in an MPC controller and I want one of the manipulated variables to have maximum effect on the output.I tried to adjust the weights of the manipulated variables but still could not get a desired effect.How to fix this issue?I am using MPC toolbox from MathWorks for designing the MPC controller.