This question doesn't clearly define your problem, so I or others will have a hard time answering you definitively.
- If you are trying to plot an equation, you need to define for yourself what the plotted region of interest should be. This is independent of whatever medium you use (whether software or just pen and paper).
- The equation you show doesn't follow matlab syntax. If I assume that you are multiplying (1/x) by the bracketed term, you should specify it as something like:
x=-100:0.1:100; %Defining the interval of interest
y=(2.125*x.^4-5.25*x.^3+12.5*x.^2+200*x+100)./x;
plot(x,y)