There is multiple ways to do this:
1- if you want to run multiple simulations, I recommend to use a SimFunction that will take a matrix of parameter values as input. Please refer to this post: Tips and Tricks: Use SimFunction for easy and fast model simulations in scripts
2- if you run a single simulation, you can create a variant with sbiovariant, add content to it with addcontent and pass it to sbiosimulate. When you pass this variant to sbiosimulate, the values in this variant will be used for simulation instead of the values stored in the model.
An easier way to create it is to use the App.
3- you can modify parameter values in the model itself. For this, you can use sbioselect to select the object corresponding to your parameter and change its value with the dot notation (parObj.Value). However, I don't recommend this method because this change will persist for the rest of your analysis, which might not be what you want.
