How to model organelle distribution?

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Rebecca Jones 2019-9-24

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关闭： MATLAB Answer Bot 2021-8-20

Hello, and thank you for looking at my question!

I would like to build a model that allows me to predict the location and distribution of lysosomes within a mammalian cell over time. Lysosomes typically cluster around the nucelus but can be encouraged to the cell periphery under different conditions (eg, pH, certain drugs). How can I go about building a model that would allow me to alter different conditions and see how it alters the distribution of lysosomes?

I realise this is a big question and would be grateful of any help at all!

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Rebecca Jones 2019-9-25

Hi Michael,

If I'd known how to, I would have! My question is basically how can I express this biological phenomenon (not a problem per se) in a mathematical way. Luckily, rough93 below seems to have gathered this and provided a helpful answer! Thank you for taking the time to comment.

Star Strider 2019-9-25

Do you already have data on the lysosome distributions, specifically with respect to pH (since that’s likely the easiest to work with)?

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Answer 1

rough93 2019-9-24

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I imagine the easiest way to achieve this would be a simple xy graph to plot your points (assuming a 2D space). To have the output affected by the inputs, you'll need to give us some more info or formaulte yourself what the equations or formaula would be to affect change (ie. what inputs creat what changes in the cell?).

Once you have your equations, you can then make a few statements in your code to take all conditions into account before giving your outputs x,y.