Problems fitting couple differential equations to experimental data

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Rosie
Rosie 2020-4-5
回答： Star Strider 2020-4-6
I'm trying to fit experimental data with a system of differential equations. So far, I've followed what was done here, as it closely resembles what I'm trying to accomplish: https://www.mathworks.com/matlabcentral/answers/254566-how-do-i-fit-coupled-differential-equations-to-experimental-data
The equations are:
dP(t)/dt = kn*(10-M(t))^nc + km*M(t) - ka*P(t)^2
dM(t)/dt = kp*(10 - M(t))*P(t)
P(0) = M(0) = 0
My data consists of time, t, and fiber mass, M(t), so essentially I want to solve for M(t) to fit the data. If it helps, the M(t) can generally be fit by a sigmoidal function, but I'm using these equations because I would like to obtain the constants kn, nc, km, ka, and kp. I know there are a lot of parameters which makes fitting harder... Here is the code:
function [x] = knfit(t,f)
% t = time
% f = raw data
function S = prefun(B,t)
% variables: x(1) = P = P(t) x(2) = M = M(t)
% parameters:
% B(1) = kn
% B(2) = nc
% B(3) = km
% B(4) = ka
% B(5) = kp;
x0 = [0 0];
[~,Sv] = ode45(@DiffEq,t,x0);
function dS = DiffEq(t,x)
dS(1,:) = B(1)*(10-x(2))^B(2) + B(3)*x(2) - B(4)*x(1)^2;
dS(2,:) = B(5)*(10-x(2))*x(1);
end
S = Sv(:,1);
end
objfcn = @(B,t) prefun(B,t);
B0 = [0.001, 2, 0.0001, 1.1, 0.00002]; % initial values
x = lsqcurvefit(objfcn,B0,t,f);
end
The errors that I get right now are:
Matrix dimensions must agree.
Error in lsqcurvefit/objective (line 279)
F = F - YDATA;
I'm super confused because the x and y data definitely are the same dimensions. Does B0 have to be something different?
I'm pretty new at this so go easy on me! :) Thanks!

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回答（2 个）

Alex Sha
Alex Sha 2020-4-6
Hi, if possible, upload your data (t, P and M) please
Star Strider
Star Strider 2020-4-6
Running your code with random data ran without error (R2020a):
t = (0:20)';
f = rand(size(t));
function [x] = knfit(t,f)
% t = time
% f = raw data
function S = prefun(B,t)
% variables: x(1) = P = P(t) x(2) = M = M(t)
% parameters:
% B(1) = kn
% B(2) = nc
% B(3) = km
% B(4) = ka
% B(5) = kp;
x0 = [0 0];
[~,Sv] = ode45(@DiffEq,t,x0);
function dS = DiffEq(t,x)
dS(1,:) = B(1)*(10-x(2))^B(2) + B(3)*x(2) - B(4)*x(1)^2;
dS(2,:) = B(5)*(10-x(2))*x(1);
end
S = Sv(:,1);
end
objfcn = @(B,t) prefun(B,t);
B0 = [0.001, 2, 0.0001, 1.1, 0.00002]; % initial values
x = lsqcurvefit(objfcn,B0,t,f);
end
x = knfit(t,f)
I am not exactly certain what the problem could be, other than it is possible that ode45 encountered a singularity (infinite value) and stopped integrating. The vectors would then not be the same lengths, however that would likely throw a different error.

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