I helped someone with a similar setup before.
Basically once you get the networking stuff set up, you set up the MJS, start the workers, and submit away.
If you wanted to, you could start workers on PC1 as well as PC2, you just have the workers on PC1 controlled by the job manager on PC2 -- although you do need to make sure you don't have too much load on PC1. A good starting point is one MATLAB per compute core, and 2 GB per worker.
You could do two workers on PC2 and three on PC1, keeping in mind you are doing other things on PC1. Tune as desired depending on how the hardware responds.
It's also recommended to keep the same bitness on the machines. Are both operating systems 32-bit? That will let you process parallel jobs most effectively.
