I don't think you can do it with xlsread function in 0.005 sec, plus the time of simulation which depends on the complexity of your model. But If you want to simulate after all data are imported, use
data=xlsread('yourfile.xlsx');
t=data(:,1);
angle=data(:,2);
speed=data(:,3);
ta=[t';angle'];
ts=[t';speed'];
save file1 ta
save file2 ts
Then use in simulink the from file block with respective names file1 and file2
