Model/Simulation of Drug Release in Graphical SimBio Interface

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Greg Jones 2020-11-23

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编辑： Jeremy Huard 2020-12-3

How can I model drug release using standard equations (e.g., Standard zero/first/second order, Higuchi, Korsemeyer-Peppas) using the graphical interface?

I would like to use the equations to describe how drug moves from a drug reservoir compartment into a compartment represting bulk solution, and then fit experimental data to get drug release parameters.

Thanks!

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Jeremy Huard 2020-11-25

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Hi Greg,

we have released video tutorials which cover different topics including model building:

SimBiology Tutorials for QSP, PBPK, and PK/PD Modeling and Analysis

Using these concepts you will be able to build any model based on ordinary differential equations.

Best regards,

Jérémy

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Jeremy Huard 2020-11-30

编辑：Jeremy Huard 2020-12-3

Hi Greg,

you can use the keyword time in SimBiology to define your own reaction rates. You can also use it in any other construct like event trigger or repeated assignments to define time-dependent algebraic equations.

Best regards,

Jérémy

Greg Jones 2020-12-3