Hi,
How about comparing the number of rows of your matrix with the number of rows after passing through the unique function:
Tst = [ 1 1 2 2;
2 2 3 1.5;
3 3 4 2.2;
4 4 5 6.8;
5 4 6 1;
6 5 7 5.1;
7 6 8 2.5;
8 7 9 3.3;
9 8 10 2.8;
10 8 11 1.4;
11 10 12 3.2;
12 11 13 2.7;
13 12 14 1.9;
14 13 15 4.5];
AllRowsAreUnique = size( Tst , 1 ) == size( unique( Tst(:,2:3) , 'rows') , 1 );