Assuming that you might be trying to run your application using XCP-based external mode, the error can could have occured because XCP-based External Mode does not generate a target data map file.
Therefore, we suspect that the the default setup of the External Mode transport layer was modified and the current values are incorrect. Please type from the MATLAB console the following commands:
>> idx = get_param(modelName, 'ExtModeTransport')
>> cs = getActiveConfigSet(modelName)
>> [transport, mexfile, interface] = Simulink.ExtMode.Transports.getExtModeTransport(cs, idx)
In order to run XCP-based External Mode, you should see the following output:
>> [transport, mexfile, interface] = Simulink.ExtMode.Transports.getExtModeTransport(cs, idx)
transport =
'XCP on TCP/IP'
mexfile =
'ext_xcp'
interface =
'Level2 - Open'