Simbiology how to simulate multiple doses in different groups

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Camila Almeida 2013-6-21

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https://ww2.mathworks.cn/matlabcentral/answers/79877-simbiology-how-to-simulate-multiple-doses-in-different-groups

Hi, it is a simple question.

I looking at simulating a 1 comp PK model for two groups. These two groups have different dose levels, and we have multiple doses (not just a single dose) for these groups.

How can I simulate that? I can't find anywhere where I can add the information about group so that I can define different dose schedules for different groups. I'm using matlab 2012b.

Thanks

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采纳的回答

Ingrid Tigges 2013-6-23

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I have two questions:

1) Are you using the SimBiology Desktop?

2) Is the only difference between the two groups the dosing?

If the answer to these two questions is yes, simply create two dosing schemes under Model => Doses and select the dosing scheme you want to use for your simulation. In case you have more differences than just the dosing between the groups you might consider creating variants and then select the dosing scheme you want to apply to each variant.

Are you aware of this document? http://www.mathworks.de/discovery/supporting-docs/using-simBiology-for-pharmacokinetic-and-mechanistic-modeling.pdf? It contains nice explanations of how certain things are done in SimBiology.