I dont believe there is a way to directly assign a vector to a comma separated list.
If you are just working with 2 variables the easiest way would be
C = inv(A)*B;
a=C(1);
b=C(2);
clear C; % so that you can free up the memory
You can however use comma separated list if you have a cell array.
C = inv(A)*B;
D = num2cell(C);
[a,b] = D{:};
clear C;
clear D;
Hope that helps.
