Running a script from a function and use the 'base' workspace for that script

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I am making a GUI using GUIDE. My intention is to have a script that is already available to be ran when pressing a push button, using the push button callback.

The script uses variables from 'base' workspace.

Naturally, MATLAB gives an error - I assume it is because anything ran from the callback function will attempt to use the callback functions workspace.

The reason why I cannot run the script from within the callback is that other functions are contained in the script, specifically ones that use a SIMULINK model. My experience with nested functions running SIMULINK models ended in avoiding the use of SIMULINK in that manner - if I have SIMULINK block fields obtain a parameter value from a workspace or put one in there, it goes into 'base'; but with nested functions MATLAB tells me that it cannot write any variables.

Hence I'd like to avoid running my script from the callback.

How could I trigger my script from the GUI pushbutton callback, but run the script in 'base' workspace?

P.S. I've considered the use of simset - it seems the function is now obsolete.