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PK modeling when PK parameters are known

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Anurag Passi
Anurag Passi 2017-6-7
评论： Arthur Goldsipe 2017-6-7
Hello, I am trying to create a PK model for the first time. However, I do not have the usual drug_conc - time curve from in-vitro data. All I have is a set of PK parameters that I have mined from literature. I want to know is there a direct way of putting these parameters directly into a one compartment model and find the secondary PK parameters. I want to then create a PD model using those estimated parameters.
Kindly help.
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Arthur Goldsipe
Arthur Goldsipe 2017-6-7
I don't fully understand your question. Can you provide more details? What are the parameters you have literature estimates for? What are the secondary parameters you would like to estimate? Do you want to create the model using SimBiology from the command line or using the desktop's graphical interface?

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