Binary file read 16bit word in 2's complement

Hi everyone, I have a binary file and I'm trying to read 16bit words (values) in 2's complement (till the end of the file). Is this something that can be done with default Matlab functions 'fread'?! Or must I use some other technique (custom functions).

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Jan
Jan 2017-10-30
What happens if you simply try it with fread? Post the code and explain the remaining problems specifically.

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raw_file = fopen([filename '.r' num2str(channels) 'a']);
raw_data = fread(raw_file, Inf, 'int16');
this is the code and while it works (well, it reads the file) I don't know if I'm reading it right.. this is a binary file from an EEG device.. so I don't know the values upfront to compare them. The device manual says:
"Each sample is a 16-bit word in 2's complement form."
This is all I have!

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