You can find the rows with the first condition and the other rows for the second condition. The intersection of the two rows, are the row numbers that satisfy both conditions:
rows = intersect(find(a(:,1)==527.1235), find(a(:,3)==927.5));
% average of the above rows
avg = mean(a(rows,4));
disp(avg)
or simpler :
rows = find(a(:,1)==527.1235 & a(:,3)==927.5);
% average of the above rows
avg = mean(a(rows,4));
disp(avg)
