Memory usage constantly growing: efficient RAM usage in my script?

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Hello,

I have a very long running MATLAB script working with variables which use 1 GB storage if I save them on harddisk with the save() command. The process goes like this: - calculating values - save values to file (1 GB) - repeat everything in a loop using the old variables

So I reuse my variables every loop iteration, but my RAM usage is constantly growing and at some point exceeds my memory and MATLAB crashes.

So my questions is: Is my process efficient with reusing my variables? I am wondering why my RAM usage is constantly growing.

Any help is welcome!